The Use of the Humanized Mouse Model in Gene Therapy and Immunotherapy for HIV and Cancer.
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ABSTRACT:
SUBMITTER: Carrillo MA
PROVIDER: S-EPMC5932400 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
The Use of the Humanized Mouse Model in Gene Therapy and Immunotherapy for HIV and Cancer.
Carrillo Mayra A MA Zhen Anjie A Kitchen Scott G SG
Frontiers in immunology 20180420
HIV and cancer remain prevailing sources of morbidity and mortality worldwide. There are current efforts to discover novel therapeutic strategies for the treatment or cure of these diseases. Humanized mouse models provide the investigative tool to study the interaction between HIV or cancer and the human immune system <i>in vivo</i>. These humanized models consist of immunodeficient mice transplanted with human cells, tissues, or hematopoietic stem cells that result in reconstitution with a near ...[more]
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