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The Prevalence of Phenylketonuria in Arab Countries, Turkey, and Iran: A Systematic Review.


ABSTRACT: Background/Objectives:This paper seeks to identify the prevalence of Phenylketonuria (PKU) in Arab countries, Turkey, and Iran. The study reviewed the existence of comprehensive national newborn screening programs and reported consanguinity rates. Methods:A computer based literature search was conducted using relevant keywords to retrieve studies conducted on PKU. A total of 34 articles were included. Prevalence was categorized based on the type of screening method used for PKU diagnoses. Results:The prevalence of classical PKU diagnosed through a comprehensive national newborn screening program ranged from 0.005% to 0.0167%. The highest prevalence was reported in Turkey at 0.0167%, whereas the lowest prevalence was reported in the UAE, 0.005%. Conclusion:The findings of this review emphasize the need for the establishment of more efficient reporting systems in these countries that would help measure Disability-Adjusted Life Year (DALY) in order to estimate the overall societal burden of PKU.

SUBMITTER: El-Metwally A 

PROVIDER: S-EPMC5932526 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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The Prevalence of Phenylketonuria in Arab Countries, Turkey, and Iran: A Systematic Review.

El-Metwally Ashraf A   Yousef Al-Ahaidib Lujane L   Ayman Sunqurah Alaa A   Al-Surimi Khaled K   Househ Mowafa M   Alshehri Ali A   Da'ar Omar B OB   Abdul Razzak Hira H   AlOdaib Ali Nasser AN  

BioMed research international 20180418


<h4>Background/objectives</h4>This paper seeks to identify the prevalence of Phenylketonuria (PKU) in Arab countries, Turkey, and Iran. The study reviewed the existence of comprehensive national newborn screening programs and reported consanguinity rates.<h4>Methods</h4>A computer based literature search was conducted using relevant keywords to retrieve studies conducted on PKU. A total of 34 articles were included. Prevalence was categorized based on the type of screening method used for PKU di  ...[more]

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