Ontology highlight
ABSTRACT:
SUBMITTER: Schauer SN
PROVIDER: S-EPMC5932605 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Schauer Stephanie N SN Carreira Patricia E PE Shukla Ruchi R Gerhardt Daniel J DJ Gerdes Patricia P Sanchez-Luque Francisco J FJ Nicoli Paola P Kindlova Michaela M Ghisletti Serena S Santos Alexandre Dos AD Rapoud Delphine D Samuel Didier D Faivre Jamila J Ewing Adam D AD Richardson Sandra R SR Faulkner Geoffrey J GJ
Genome research 20180411 5
The retrotransposon Long Interspersed Element 1 (LINE-1 or L1) is a continuing source of germline and somatic mutagenesis in mammals. Deregulated L1 activity is a hallmark of cancer, and L1 mutagenesis has been described in numerous human malignancies. We previously employed retrotransposon capture sequencing (RC-seq) to analyze hepatocellular carcinoma (HCC) samples from patients infected with hepatitis B or hepatitis C virus and identified L1 variants responsible for activating oncogenic pathw ...[more]