Ontology highlight
ABSTRACT:
SUBMITTER: Lannon SM
PROVIDER: S-EPMC5933184 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Reproductive sciences (Thousand Oaks, Calif.) 20140519 10
Preterm premature rupture of membranes (PPROM) occurs in 1% to 2% of births. Impact of PPROM is greatest in low- and middle-income countries where prematurity-related deaths are most common. Recent investigations identify cytokine and matrix metalloproteinase activation, oxidative stress, and apoptosis as primary pathways to PPROM. These biological processes are initiated by heterogeneous etiologies including infection/inflammation, placental bleeding, uterine overdistention, and genetic polymor ...[more]