Elevated androstenedione in young adult but not early adolescent prenatally androgenized female rats.

ABSTRACT:

Background

Elevated testosterone (T) is routinely reported as a marker of hyperandrogenemia in rodent models for polycystic ovary syndrome (PCOS). In women with PCOS, elevated serum androstenedione (A4) is associated with more severe phenotypes, including a positive correlation with serum T, DHEAS, free androgen index (FAI), LH, and LH/FSH ratio. Furthermore, A4, along with calculated free T and FAI, was identified as one of the best predictors of PCOS in adult women of all ages (18 to > 50 y).

Objective

The objective of this study was to investigate serum A4 levels in early adolescent and young adult prenatally androgenized (PNA) female rats, a model for PCOS.

Methods

Pregnant rats were injected with 5 mg T daily during gestational days 16-19 (PNA rats, experimental

SUBMITTER: Shah AB 

PROVIDER: S-EPMC5933698 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature