Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types.
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ABSTRACT:
SUBMITTER: Seiler M
PROVIDER: S-EPMC5933844 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Publications
Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types.
Seiler Michael M Peng Shouyong S Agrawal Anant A AA Palacino James J Teng Teng T Zhu Ping P Smith Peter G PG Buonamici Silvia S Yu Lihua L
Cell reports 20180401 1
Hotspot mutations in splicing factor genes have been recently reported at high frequency in hematological malignancies, suggesting the importance of RNA splicing in cancer. We analyzed whole-exome sequencing data across 33 tumor types in The Cancer Genome Atlas (TCGA), and we identified 119 splicing factor genes with significant non-silent mutation patterns, including mutation over-representation, recurrent loss of function (tumor suppressor-like), or hotspot mutation profile (oncogene-like). Fu ...[more]
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