Different Neuronal Activity Patterns Induce Different Gene Expression Programs.

ABSTRACT: A vast number of different neuronal activity patterns could each induce a different set of activity-regulated genes. Mapping this coupling between activity pattern and gene induction would allow inference of a neuron's activity-pattern history from its gene expression and improve our understanding of activity-pattern-dependent synaptic plasticity. In genome-scale experiments comparing brief and sustained activity patterns, we reveal that activity-duration history can be inferred from gene expression profiles. Brief activity selectively induces a small subset of the activity-regulated gene program that corresponds to the first of three temporal waves of genes induced by sustained activity. Induction of these first-wave genes is mechanistically distinct from that of the later waves because i

SUBMITTER: Tyssowski KM 

PROVIDER: S-EPMC5934296 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature