Ontology highlight
ABSTRACT:
SUBMITTER: Arey RN
PROVIDER: S-EPMC5934306 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Arey Rachel N RN Stein Geneva M GM Kaletsky Rachel R Kauffman Amanda A Murphy Coleen T CT
Neuron 20180412 3
Perhaps the most devastating decline with age is the loss of memory. Therefore, identifying mechanisms to restore memory function with age is critical. Using C. elegans associative learning and memory assays, we identified a gain-of-function G<sub>αq</sub> signaling pathway mutant that forms a long-term (cAMP response element binding protein [CREB]-dependent) memory following one conditioned stimulus-unconditioned stimulus (CS-US) pairing, which usually requires seven CS-US pairings. Increased C ...[more]