Ontology highlight
ABSTRACT:
SUBMITTER: Wray NR
PROVIDER: S-EPMC5934326 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Nature genetics 20180426 5
Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls and identified 44 independent and significant loci. The genetic findings were associated with clinical features of major depression and implicated brain regions exhibiting anatomical differences in cases. Targets of antidepressant medications and genes involved ...[more]