Ontology highlight
ABSTRACT:
SUBMITTER: Alejo A
PROVIDER: S-EPMC5934441 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Alejo Alí A Ruiz-Argüello M Begoña MB Pontejo Sergio M SM Fernández de Marco María Del Mar MDM Saraiva Margarida M Hernáez Bruno B Alcamí Antonio A
Nature communications 20180503 1
The role of cytokines and chemokines in anti-viral defense has been demonstrated, but their relative contribution to protective anti-viral responses in vivo is not fully understood. Cytokine response modifier D (CrmD) is a secreted receptor for TNF and lymphotoxin containing the smallpox virus-encoded chemokine receptor (SECRET) domain and is expressed by ectromelia virus, the causative agent of the smallpox-like disease mousepox. Here we show that CrmD is an essential virulence factor that cont ...[more]