Tumor cure by radiation therapy and checkpoint inhibitors depends on pre-existing immunity.
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ABSTRACT:
SUBMITTER: Crittenden MR
PROVIDER: S-EPMC5934473 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Tumor cure by radiation therapy and checkpoint inhibitors depends on pre-existing immunity.
Crittenden Marka R MR Zebertavage Lauren L Kramer Gwen G Bambina Shelly S Friedman David D Troesch Victoria V Blair Tiffany T Baird Jason R JR Alice Alejandro A Gough Michael J MJ
Scientific reports 20180503 1
Radiation therapy is a source of tumor antigen release that has the potential to serve as an endogenous tumor vaccination event. In preclinical models radiation therapy synergizes with checkpoint inhibitors to cure tumors via CD8 T cell responses. To evaluate the immune response initiated by radiation therapy, we used a range of approaches to block the pre-existing immune response artifact initiated by tumor implantation. We demonstrate that blocking immune responses at tumor implantation blocks ...[more]
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