Ontology highlight
ABSTRACT:
SUBMITTER: Zhu JY
PROVIDER: S-EPMC5935450 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Zhu Jia-Ying JY Li Yuyao Y Cao Dong-Mei DM Yang Hongjuan H Oh Eunkyoo E Bi Yang Y Zhu Shengwei S Wang Zhi-Yong ZY
Molecular cell 20170601 5
The glycogen synthase kinase-3 (GSK3) family kinases are central cellular regulators highly conserved in all eukaryotes. In Arabidopsis, the GSK3-like kinase BIN2 phosphorylates a range of proteins to control broad developmental processes, and BIN2 is degraded through unknown mechanism upon receptor kinase-mediated brassinosteroid (BR) signaling. Here we identify KIB1 as an F-box E3 ubiquitin ligase that promotes the degradation of BIN2 while blocking its substrate access. Loss-of-function mutat ...[more]