Ontology highlight
ABSTRACT:
SUBMITTER: Hunt HB
PROVIDER: S-EPMC5935591 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Hunt Heather B HB Pearl Jared C JC Diaz David R DR King Karen B KB Donnelly Eve E
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20180208 5
Type 2 diabetes mellitus (T2DM) increases fracture risk for a given bone mineral density (BMD), which suggests that T2DM changes bone tissue properties independently of bone mass. In this study, we assessed the effects of hyperglycemia on bone tissue compositional properties, enzymatic collagen crosslinks, and advanced glycation end-products (AGEs) in the KK-Ay murine model of T2DM using Fourier transform infrared (FTIR) imaging and high-performance liquid chromatography (HPLC). Compared to KK-a ...[more]