Ontology highlight
ABSTRACT:
SUBMITTER: Nagata K
PROVIDER: S-EPMC5935712 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Nagata Kenichi K Takahashi Mika M Matsuba Yukio Y Okuyama-Uchimura Fumi F Sato Kaori K Hashimoto Shoko S Saito Takashi T Saido Takaomi C TC
Nature communications 20180504 1
Although, a number of pathogenic mutations have been found for Alzheimer's disease (AD), only one protective mutation has been identified so far in humans. Here we identify possible protective deletion mutations in the 3'-UTR of the amyloid precursor protein (App) gene in mice. We use an App knock-in mouse model carrying a humanized Aβ sequence and three AD mutations in the endogenous App gene. Genome editing of the model zygotes using multiple combinations of CRISPR/Cas9 tools produces genetica ...[more]