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Effects of simvastatin in chronic obstructive pulmonary disease: Results of a pilot, randomized, placebo-controlled clinical trial.


ABSTRACT: Introduction:Statins may have pleiotropic effects in COPD, but mechanisms remain unclear. Objectives:To assess the pleiotropic effect of statins in patients with stable COPD on (1): lung function (2); pulmonary and systemic inflammation (3); endothelial function (vascular stiffness) and circulating vascular growth factors; and (4), serum uric acid levels. Method:Pilot, double-blind, randomized, placebo-controlled clinical trial in 24 patients with stable COPD, all statin-naïve, who were randomized (1:1) to receive simvastatin 40 mg/24 h during 12 weeks (n = 12; 69.0 ± 7.3 years; post-bd FEV1 53.4 ± 10.0% pred.) or placebo (n = 12; 66.4 ± 4.6 years; post-bd FEV1 48.2 ± 12.6% pred.). Nine patients per group (total n = 18) completed the study. Results:Lung function, pulmonary and systemic inflammatory markers and the degree of vascular stiffness did not change significantly in any group. However, treatment with simvastatin increased the plasma levels of erythropoietin (Epo) (4.2 ± 2.2 mIU/mL to 6.8 ± 3.2 mlU/mL, p < 0.05) and reduced those of serum uric acid (7.1 ± 1.3 mg/dL to 6.5 ± 1.4 mg/dL, p < 0.01). Conclusions:Short-term treatment with simvastatin in stable COPD patients did not modify lung function, pulmonary and systemic inflammation, or vascular stiffness, but it changed Epo and uric acid levels.

SUBMITTER: Balaguer C 

PROVIDER: S-EPMC5935853 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Effects of simvastatin in chronic obstructive pulmonary disease: Results of a pilot, randomized, placebo-controlled clinical trial.

Balaguer Catalina C   Peralta Alejandro A   Ríos Ángel Á   Iglesias Amanda A   Valera Josep Lluís JL   Noguera Aina A   Soriano Joan B JB   Agustí Àlvar À   Sala-Llinas Ernest E  

Contemporary clinical trials communications 20160114


<h4>Introduction</h4>Statins may have pleiotropic effects in COPD, but mechanisms remain unclear.<h4>Objectives</h4>To assess the pleiotropic effect of statins in patients with stable COPD on (<i>1</i>): lung function (<i>2</i>); pulmonary and systemic inflammation (<i>3</i>); endothelial function (vascular stiffness) and circulating vascular growth factors; and (<i>4</i>), serum uric acid levels.<h4>Method</h4>Pilot, double-blind, randomized, placebo-controlled clinical trial in 24 patients wit  ...[more]

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