From in silico to in vitro: a trip to reveal flavonoid binding on the Rattus norvegicus Kir6.1 ATP-sensitive inward rectifier potassium channel.

ABSTRACT:

Background

ATP-sensitive inward rectifier potassium channels (Kir), are a potassium channel family involved in many physiological processes. K_ATP dysfunctions are observed in several diseases such as hypoglycaemia, hyperinsulinemia, Prinzmetal angina-like symptoms, cardiovascular diseases.

Methods

A broader view of the K_ATP mechanism is needed in order to operate on their regulation, and in this work we clarify the structure of the Rattus norvegicus ATP-sensitive inward rectifier potassium channel 8 (Kir6.1), which has been obtained through a homology modelling procedure. Due to the medical use of flavonoids, a considerable increase in studies on their influence on human health has recently been observed, therefore our aim is to study, through co

SUBMITTER: Trezza A 

PROVIDER: S-EPMC5936070 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature