Ontology highlight
ABSTRACT:
SUBMITTER: Benitez Cardenas AS
PROVIDER: S-EPMC5936680 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Benitez Cardenas Andres S AS Samuel Premila P PP Olson John S JS
Shock (Augusta, Ga.) 20191001 1S Suppl 1
This article reviews the key biochemical mechanisms that govern O2 transport, NO scavenging, and oxidative degradation of acellular hemoglobin (Hb) and how these ideas have been used to try to develop strategies to engineer safer and more effective hemoglobin-based oxygen carriers (HBOCs). Significant toxicities due to acellular Hb have been observed after the administration of HBOCs or after the lysis of red cells, and include rapid clearance and kidney damage due to dissociation into dimers, h ...[more]