Ontology highlight
ABSTRACT:
SUBMITTER: Wang F
PROVIDER: S-EPMC5936715 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Open biology 20180401 4
Nanoparticles (NPs) typically accumulate in lysosomes. However, their impact on lysosomal function, as well as autophagy, a lysosomal degradative pathway, is still not well known. We have previously reported in the 1321N1 cell line that amine-modified polystyrene (NH<sub>2</sub>-PS) NPs induce apoptosis through damage initiated in the lysosomes leading ultimately to release of lysosomal content in the cytosol, followed by apoptosis. Here, by using a combination of biochemical and cell biological ...[more]