The relationship between substrate morphology and biological performances of nano-silver-loaded dopamine coatings on titanium surfaces.

ABSTRACT: Biomedical device-associated infection (BAI) and lack of osseointegration are the main causes of implant failure. Therefore, it is imperative for implants not only to depress microbial activity and biofilm colonization but also to prompt osteoblast functions and osseointegration. As part of the coating development for implants, the interest of in vitro studies on the interaction between implant substrate morphology and the coating's biological performances is growing. In this study, by harnessing the adhesion and reactivity of bioinspired polydopamine, nano-silver was successfully anchored onto micro/nanoporous as well as smooth titanium surfaces to analyse the effect of substrate morphology on biological performances of the coatings. Compared with the smooth surface, a small size o

SUBMITTER: Zhang W 

PROVIDER: S-EPMC5936945 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature