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Genetics and Genomics of Social Behavior in a Chicken Model.

ABSTRACT: The identification of genes affecting sociality can give insights into the maintenance and development of sociality and personality. In this study, we used the combination of an advanced intercross between wild and domestic chickens with a combined QTL and eQTL genetical genomics approach to identify genes for social reinstatement, a social and anxiety-related behavior. A total of 24 social reinstatement QTL were identified and overlaid with over 600 eQTL obtained from the same birds using hypothalamic tissue. Correlations between overlapping QTL and eQTL indicated five strong candidate genes, with the gene TTRAP being strongly significantly correlated with multiple aspects of social reinstatement behavior, as well as possessing a highly significant eQTL.

SUBMITTER: Johnsson M

PROVIDER: S-EPMC5937196 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Genetics and Genomics of Social Behavior in a Chicken Model.

Johnsson Martin M Henriksen Rie R Fogelholm Jesper J Höglund Andrey A Jensen Per P Wright Dominic D

Genetics 20180312 1

The identification of genes affecting sociality can give insights into the maintenance and development of sociality and personality. In this study, we used the combination of an advanced intercross between wild and domestic chickens with a combined QTL and eQTL genetical genomics approach to identify genes for social reinstatement, a social and anxiety-related behavior. A total of 24 social reinstatement QTL were identified and overlaid with over 600 eQTL obtained from the same birds using hypot ...[more]

PMID: 29531010

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