Ontology highlight
ABSTRACT:
SUBMITTER: Finley LWS
PROVIDER: S-EPMC5937285 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Finley Lydia W S LWS Vardhana Santosha A SA Carey Bryce W BW Alonso-Curbelo Direna D Koche Richard R Chen Yanyang Y Wen Duancheng D King Bryan B Radler Megan R MR Rafii Shahin S Lowe Scott W SW Allis C David CD Thompson Craig B CB
Nature cell biology 20180416 5
A robust network of transcription factors and an open chromatin landscape are hallmarks of the naive pluripotent state. Recently, the acetyllysine reader Brd4 has been implicated in stem cell maintenance, but the relative contribution of Brd4 to pluripotency remains unclear. Here, we show that Brd4 is dispensable for self-renewal and pluripotency of embryonic stem cells (ESCs). When maintained in their ground state, ESCs retain transcription factor binding and chromatin accessibility independent ...[more]