Ontology highlight
ABSTRACT:
SUBMITTER: Reagh ZM
PROVIDER: S-EPMC5937538 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Reagh Zachariah M ZM Noche Jessica A JA Tustison Nicholas J NJ Delisle Derek D Murray Elizabeth A EA Yassa Michael A MA
Neuron 20180301 5
The entorhinal cortex (EC) is among the earliest brain areas to deteriorate in Alzheimer's disease (AD). However, the extent to which functional properties of the EC are altered in the aging brain, even in the absence of clinical symptoms, is not understood. Recent human fMRI studies have identified a functional dissociation within the EC, similar to what is found in rodents. Here, we used high-resolution fMRI to identify a specific hypoactivity in the anterolateral EC (alEC) commensurate with m ...[more]