Ontology highlight
ABSTRACT:
SUBMITTER: Germano A
PROVIDER: S-EPMC5937768 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Germano Antonina A Saba Laura L De Francia Silvia S Rapa Ida I Perotti Paola P Berruti Alfredo A Volante Marco M Terzolo Massimo M
PloS one 20180507 5
Mitotane is the reference drug for adrenocortical carcinoma (ACC) and the metabolic activation of the drug is considered as essential for its activity. The aim of this study was to assess the role of CYP11B1 on mitotane action and metabolism in H295R ACC cells to understand whether this enzyme may influence mitotane action. The simultaneous incubation with mitotane and metyrapone, an adrenolytic molecule targeting 11-beta-hydroxylase, did not influence mitotane-mediated cytotoxic effect and meta ...[more]