Ontology highlight
ABSTRACT:
SUBMITTER: Slayton M
PROVIDER: S-EPMC5937935 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Virology 20180405
The human cytomegalovirus (HCMV) UL34 gene encodes sequence-specific DNA-binding proteins (pUL34) which are required for viral replication. Interactions of pUL34 with DNA binding sites represses transcription of two viral immune evasion genes, US3 and US9. 12 additional predicted pUL34-binding sites are present in the HCMV genome (strain AD169) with three binding sites concentrated near the HCMV origin of lytic replication (oriLyt). We used ChIP-seq analysis of pUL34-DNA interactions to confirm ...[more]