Ontology highlight
ABSTRACT:
SUBMITTER: Mu G
PROVIDER: S-EPMC5938061 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Mu Ganggang G Ding Qianshan Q Li Hongyan H Zhang Li L Zhang Lingli L He Ke K Wu Lu L Deng Yunchao Y Yang Dongmei D Wu Lianlian L Xu Ming M Zhou Jie J Yu Honggang H
Experimental & molecular medicine 20180501 5
The mechanism by which gastrin promotes pancreatic cancer cell metastasis is unclear. The process of directing polarized cancer cells toward the extracellular matrix is principally required for invasion and distant metastasis; however, whether gastrin can induce this process and its underlying mechanism remain to be elucidated. In this study, we found that gastrin-induced phosphorylation of paxillin at tyrosine 31/118 and RhoA activation as well as promoted the metastasis of PANC-1 cancer cells. ...[more]