Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages.

ABSTRACT:

Introduction

Genetic associations for endophenotypes of Alzheimer's disease (AD) in cognitive stages preceding AD have not been thoroughly evaluated.

Methods

We conducted genome-wide association studies for AD-related endophenotypes including hippocampal volume, logical memory scores, and cerebrospinal fluid Aβ₄₂ and total/phosphorylated tau in cognitively normal (CN), mild cognitive impairment, and AD dementia subjects from the Alzheimer's Disease Neuroimaging Initiative study.

Results

In CN subjects, study-wide significant (P < 8.3 × 10^-9) loci were identified for total tau near SRRM4 and C14orf79 and for hippocampal volume near MTUS1. In mild cognitive impairment subjects, study-wide significant association was found with single nucleotide pol

SUBMITTER: Chung J 

PROVIDER: S-EPMC5938137 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature