Ontology highlight
ABSTRACT:
SUBMITTER: Liu Q
PROVIDER: S-EPMC5938394 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Frontiers in pharmacology 20180501
Mequindox (MEQ), belonging to quinoxaline-di-<i>N</i>-oxides (QdNOs), is a synthetic antimicrobial agent widely used in China. Previous studies found that the kidney was one of the main toxic target organs of the QdNOs. However, the mechanisms underlying the kidney toxicity caused by QdNOs <i>in vivo</i> still remains unclear. The present study aimed to explore the molecular mechanism of kidney toxicity in mice after chronic exposure to MEQ. MEQ led to the oxidative stress, apoptosis, and mitoch ...[more]