Ontology highlight
ABSTRACT:
SUBMITTER: Bhatt DK
PROVIDER: S-EPMC5938891 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Bhatt Deepak Kumar DK Basit Abdul A Zhang Haeyoung H Gaedigk Andrea A Lee Seung-Been SB Claw Katrina G KG Mehrotra Aanchal A Chaudhry Amarjit Singh AS Pearce Robin E RE Gaedigk Roger R Broeckel Ulrich U Thornton Timothy A TA Nickerson Deborah A DA Schuetz Erin G EG Amory John K JK Leeder J Steven JS Prasad Bhagwat B
Drug metabolism and disposition: the biological fate of chemicals 20180330 6
The major objective of this study was to investigate the association of genetic and nongenetic factors with variability in protein abundance and in vitro activity of the androgen-metabolizing enzyme UGT2B17 in human liver microsomes (<i>n</i> = 455). UGT2B17 abundance was quantified by liquid chromatography-tandem mass spectrometry proteomics, and enzyme activity was determined by using testosterone and dihydrotestosterone as in vitro probe substrates. Genotyping or gene resequencing and mRNA ex ...[more]