Ontology highlight
ABSTRACT:
SUBMITTER: Poreba M
PROVIDER: S-EPMC5939596 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Poreba Marcin M Solberg Rigmor R Rut Wioletta W Lunde Ngoc Nguyen NN Kasperkiewicz Paulina P Snipas Scott J SJ Mihelic Marko M Turk Dusan D Turk Boris B Salvesen Guy S GS Drag Marcin M
Cell chemical biology 20160728 8
Legumain (AEP) is a lysosomal cysteine protease that was first characterized in leguminous seeds and later discovered in higher eukaryotes. AEP upregulation is linked to a number of diseases including inflammation, arteriosclerosis, and tumorigenesis. Thus this protease is an excellent molecular target for the development of new chemical markers. We deployed a hybrid combinatorial substrate library (HyCoSuL) approach to obtain P1-Asp fluorogenic substrates and biotin-labeled inhibitors that targ ...[more]