A Nonhuman Primate Model for Rectally Transmitted Syphilis.
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ABSTRACT:
SUBMITTER: Tansey C
PROVIDER: S-EPMC5939619 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
A Nonhuman Primate Model for Rectally Transmitted Syphilis.
Tansey Cassandra C Zhao Chunxia C Hopkins Andre A Ritter Jana M JM Fakile Yetunde F YF Pillay Allan A Katz Samantha S SS Pereira Lara L Mitchell James J Deyounks Frank F Kersh Ellen N EN McNicholl Janet M JM Vishwanathan Sundaram Ajay SA
The Journal of infectious diseases 20180301 7
Among men who have sex with men (MSM), those with a diagnosis of syphilis or other rectal sexually transmitted infections (STIs) are at a higher risk for human immunodeficiency virus acquisition, which is concerning given the large increase in recently reported syphilis cases in the United States. We have developed the first nonhuman primate model for rectally transmitted syphilis by exposing simian/human immunodeficiency virus-infected and naive rhesus macaques to Treponema pallidum in the rect ...[more]
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