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Pathology-MRI Correlations in Diffuse Low-Grade Epilepsy Associated Tumors.

ABSTRACT: It is recognized that IDH mutation negative, low-grade epilepsy associated tumors (LEAT) can show diffuse growth patterns and lack the diagnostic hallmarks of either classical dysembryoplastic neuroepithelial tumors (DNT) or typical ganglioglioma. "Nonspecific or diffuse DNT" and more recently "polymorphous low-grade neuroepithelial tumor of the young" have been terms used for these entities. There are few reports on the MRI recognition of these diffuse glioneuronal tumors (dGNT), which is important in planning the extent of surgical resection. In 27 LEATs T1, T2, FLAIR, and postcontrast T1 MRI were evaluated and the pathology reviewed, including immunostaining for NeuN, CD34, MAP2, and IDH1. Each case was then independently classified by pathology or MRI as simple DNT, complex DNT, or dGNT. There was agreement in 23/27 (85%; Kappa score 0.62; p?

SUBMITTER: Al-Hajri A

PROVIDER: S-EPMC5939705 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Pathology-MRI Correlations in Diffuse Low-Grade Epilepsy Associated Tumors.

Al-Hajri Aliya A Al-Mughairi Salim S Somani Alyma A An Shu S Liu Joan J Miserocchi Anna A McEvoy Andrew W AW Yousry Tarek T Hoskote Chandrashekar C Thom Maria M

Journal of neuropathology and experimental neurology 20171201 12

It is recognized that IDH mutation negative, low-grade epilepsy associated tumors (LEAT) can show diffuse growth patterns and lack the diagnostic hallmarks of either classical dysembryoplastic neuroepithelial tumors (DNT) or typical ganglioglioma. "Nonspecific or diffuse DNT" and more recently "polymorphous low-grade neuroepithelial tumor of the young" have been terms used for these entities. There are few reports on the MRI recognition of these diffuse glioneuronal tumors (dGNT), which is impor ...[more]

PMID: 29040640

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