Ontology highlight
ABSTRACT:
SUBMITTER: Yaffe D
PROVIDER: S-EPMC5940252 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Yaffe Dana D Forrest Lucy R LR Schuldiner Shimon S
The Journal of general physiology 20180417 5
The H<sup>+</sup>-coupled vesicular monoamine transporter (VMAT) is a transporter essential for life. VMAT mediates packaging of the monoamines serotonin, dopamine, norepinephrine, and histamine from the neuronal cytoplasm into presynaptic vesicles, which is a key step in the regulated release of neurotransmitters. However, a detailed understanding of the mechanism of VMAT function has been limited by the lack of availability of high-resolution structural data. In recent years, a series of studi ...[more]