Ontology highlight
ABSTRACT:
SUBMITTER: MacGregor TP
PROVIDER: S-EPMC5940885 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
MacGregor T P TP Carter R R Gillies R S RS Findlay J M JM Kartsonaki C C Castro-Giner F F Sahgal N N Wang L M LM Chetty R R Maynard N D ND Cazier J B JB Buffa F F McHugh P J PJ Tomlinson I I Middleton M R MR Sharma R A RA
Scientific reports 20180508 1
Oxaliplatin-based chemotherapy is used to treat patients with esophageal adenocarcinoma (EAC), but no biomarkers are currently available for patient selection. We performed a prospective, clinical trial to identify potential biomarkers associated with clinical outcomes. Tumor tissue was obtained from 38 patients with resectable EAC before and after 2 cycles of oxaliplatin-fluorouracil chemotherapy. Pre-treatment mRNA expression of 280 DNA repair (DNAR) genes was tested for association with histo ...[more]