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Gender difference in the effects of interleukin-6 on grip strength - a systematic review and meta-analysis.

ABSTRACT: BACKGROUND:Aging sarcopenia characterized by low muscle mass with low muscle strength affects men and women differently. The contribution of interleukin-6 (IL-6) to sarcopenia has been suggested based on a negative correlation between plasma IL-6 and muscle function described by some studies. However, no consensus regarding clinically relevant cut-off criteria has been reached. Another question arises whether pooling male and female data is an accurate way to determine the predictive value of IL-6 in sarcopenia. The present meta-analysis was designed to assess: (1) whether plasma IL-6 in aged populations in fact correlates negatively to muscle strength; (2) whether such a correlation exists both in men and in women; and (3) whether plasma IL-6 shows a gender difference in old age. METHODS:We applied the preferred reporting items for systematic review and meta-analysis protocols (PRISMA). We searched PubMed and Embase for papers that reported data on individuals over 65 without inflammatory diseases. We extracted either separate male and female data on plasma IL-6 along with at least one muscle parameter or correlation coefficient between plasma IL-6 and these parameters. Random effect models calculated with DerSimonian and Laird weighting methods were applied to analyze correlation coefficients and gender difference in plasma IL-6. Egger's test was used to assess the small study effect. RESULTS:Twenty articles out of 468 records identified were suitable for analyses. Plasma IL-6 correlates negatively with grip strength in mixed populations and also separately in men [-?0.25 with 95% confidence interval (CI): -?0.48, -?0.02] and in women (-?0.14 with 95% CI: -?0.24, -?0.03). However, contrary to expectations, men with better muscle condition have higher plasma IL-6 than women of similar age with worse muscle condition (plasma IL-6 male-female difference: 0.25 pg/mL with 95% CI: 0.15, 0.35). CONCLUSION:This is the first study to demonstrate that a higher predictive IL-6 cut-off level should be determined for aging sarcopenia in men than in women.

SUBMITTER: Miko A

PROVIDER: S-EPMC5941705 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Gender difference in the effects of interleukin-6 on grip strength - a systematic review and meta-analysis.

Mikó Alexandra A Pótó László L Mátrai Péter P Hegyi Péter P Füredi Nóra N Garami András A Illés Anita A Solymár Margit M Vincze Áron Á Balaskó Márta M Pár Gabriella G Sarlós Patrícia P Bajor Judit J Tenk Judit J Rostás Ildikó I Pétervári Erika E

BMC geriatrics 20180508 1

<h4>Background</h4>Aging sarcopenia characterized by low muscle mass with low muscle strength affects men and women differently. The contribution of interleukin-6 (IL-6) to sarcopenia has been suggested based on a negative correlation between plasma IL-6 and muscle function described by some studies. However, no consensus regarding clinically relevant cut-off criteria has been reached. Another question arises whether pooling male and female data is an accurate way to determine the predictive val ...[more]

PMID: 29739343

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Project description:Background and objectivesPrevious researches have reported the controversial results regarding the gender difference in clinical outcomes of patients with coronary artery disease after percutaneous coronary intervention. Hence, this systematic review and meta-analysis was designed to investigate whether gender difference existed in patients with coronary artery disease after percutaneous coronary intervention.MethodsPubMed, Embase, and the Cochrane Library database were searched up to February 10, 2018. Studies comparing the gender-specific effect on clinical outcomes of patients with coronary artery disease after percutaneous coronary intervention were identified, to analyze mortality, major adverse cardiovascular events (MACE) and revascularization. Statistical software RevMan was utilized in this meta-analysis.ResultsA total of 49 studies, involving 1,032,828 patients (774,115 males and 258,713 females) reporting gender-specific outcomes, were included in this study. The in-hospital mortality, 30-day mortality, 1-year mortality, and at least 2-years mortality in male patients with coronary artery disease after percutaneous coronary intervention were significantly lower than those of females (odds ratio [OR] 0.58 95% confidence interval [CI] 0.52-0.63, P?<?.001; OR 0.64, 95% CI 0.61-0.66, P?=?.04; OR 0.67, 95% CI 0.60-0.75, P?<?.001 and OR 0.71, 95% CI 0.63-0.79, P?=?.005, respectively). The MACE was significantly decreased in male subjects after initial percutaneous coronary intervention compared with females in <1-year or at least 1-year (OR 0.67, 95% CI 0.56-0.80, P?<?.001 and OR 0.84, 95% CI 0.76-0.93, P?<?.001). The male patients after percutaneous coronary intervention harbored higher rate of revascularization compared with females for at least 1-year (OR 1.17, 95% CI 1.00-1.36, P?<?.001), while the rate of revascularization in male patients for < 1-year was lower than that of females (OR 0.93, 95% CI 0.69-1.26, P?<?.001).ConclusionsThe systematic review and meta-analysis suggests that the prognosis of male patients with coronary artery disease after percutaneous coronary intervention is better than that of females, except for long-term revascularization.

Dataset Information

Gender difference in the effects of interleukin-6 on grip strength - a systematic review and meta-analysis.

Publications

Gender difference in the effects of interleukin-6 on grip strength - a systematic review and meta-analysis.

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