Ontology highlight
ABSTRACT:
SUBMITTER: Kohen R
PROVIDER: S-EPMC5942482 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Kohen Ruth R Tracy Julia H JH Haugen Eric E Cain Kevin C KC Jarrett Monica E ME Heitkemper Margaret M MM
Biological research for nursing 20160224 4
Alterations in serotonin signaling are suspected in the pathophysiology of irritable bowel syndrome (IBS). By modulating the extracellular reuptake of serotonin, the serotonin transporter (SERT) acts as a key regulator of the bioavailability of serotonin. This study is the first to investigate the impact of rare SERT variants (i.e., those with a minor allele frequency of < 1%) on the risk for IBS, gastrointestinal (GI) symptom level, response to cognitive-behavioral treatment, and psychiatric co ...[more]