Ontology highlight
ABSTRACT:
SUBMITTER: Ni T
PROVIDER: S-EPMC5943054 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Ni Tao T Williams Sophie I SI Rezelj Saša S Anderluh Gregor G Harlos Karl K Stansfeld Phillip J PJ Gilbert Robert J C RJC
Science advances 20180321 3
<i>Toxoplasma</i> and <i>Plasmodium</i> are the parasitic agents of toxoplasmosis and malaria, respectively, and use perforin-like proteins (PLPs) to invade host organisms and complete their life cycles. The <i>Toxoplasma gondii</i> PLP1 (<i>Tg</i>PLP1) is required for efficient exit from parasitophorous vacuoles in which proliferation occurs. We report structures of the membrane attack complex/perforin (MACPF) and Apicomplexan PLP C-terminal β-pleated sheet (APCβ) domains of <i>Tg</i>PLP1. The ...[more]