Retracted: Serum 25-hydroxyvitamin D and risk of type 2 diabetes in older adults: A dose-response meta-analysis of prospective cohort studies.

ABSTRACT: Lower serum level of 25-hydroxyvitamin D is common in older adults and associated with several negative outcomes. However, previous studies have indicated that 25-hydroxyvitamin D is associated with risk of type 2 diabetes, but presented controversial results.Studies in PubMed and EMBASE were searched update to June 2017 to identify and quantify the potential dose-response association between low 25-hydroxyvitamin D and risk of type 2 diabetes in older adults.Nine eligible studies involving a total of 34,511 participants with 2863 incident cases were included in this meta-analysis. Our results showed statistically significant association between lower 25-hydroxyvitamin D and type 2 diabetes in older adults [odds ratio (OR)?=?1.19, 95% confidence interval (95% CI): 1.08-1.32, P?=?.001]. In addition, we obtained the best fit at an inflection point of decrease 10?ng/mL in piecewise regression analysis; the summary relative risk of type 2 diabetes in older adults for a decrease of 10?ng/mL 25-hydroxyvitamin D was 1.06 (95% CI: 1.02-1.13, P?

SUBMITTER: Cheng P 

PROVIDER: S-EPMC5943125 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature