Ontology highlight
ABSTRACT:
SUBMITTER: Maeng H
PROVIDER: S-EPMC5943163 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Current opinion in immunology 20180316
Therapeutic cancer vaccines have been a long-sought approach to harness the exquisite specificity of the immune system to treat cancer, but until recently have not had much success as single agents in clinical trials. However, new understanding of the immunoregulatory mechanisms exploited by cancers has allowed the development of approaches to potentiate the effect of vaccines by removing the brakes while the vaccines step on the accelerator. Thus, vaccines that had induced a strong T cell respo ...[more]