Ontology highlight
ABSTRACT:
SUBMITTER: Katschke KJ
PROVIDER: S-EPMC5943270 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Katschke Kenneth J KJ Xi Hongkang H Cox Christian C Truong Tom T Malato Yann Y Lee Wyne P WP McKenzie Brent B Arceo Rommel R Tao Jianhua J Rangell Linda L Reichelt Mike M Diehl Lauri L Elstrott Justin J Weimer Robby M RM van Lookeren Campagne Menno M
Scientific reports 20180509 1
Geographic atrophy (GA), the advanced form of dry age-related macular degeneration (AMD), is characterized by progressive loss of retinal pigment epithelium cells and photoreceptors in the setting of characteristic extracellular deposits and remains a serious unmet medical need. While genetic predisposition to AMD is dominated by polymorphisms in complement genes, it remains unclear how complement activation contributes to retinal atrophy. Here we demonstrate that complement is activated on phot ...[more]