Ontology highlight
ABSTRACT:
SUBMITTER: Wang GQ
PROVIDER: S-EPMC5943271 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Wang Gao-Qian GQ Chen Guo-Dong GD Qin Sheng-Ying SY Hu Dan D Awakawa Takayoshi T Li Shao-Yang SY Lv Jian-Ming JM Wang Chuan-Xi CX Yao Xin-Sheng XS Abe Ikuro I Gao Hao H
Nature communications 20180509 1
Furanosteroids, represented by wortmannin, viridin, and demethoxyviridin, are a special group of fungal-derived, highly oxygenated steroids featured by an extra furan ring. They are well-known nanomolar-potency inhibitors of phosphatidylinositol 3-kinase and widely used in biological studies. Despite their importance, the biosyntheses of these molecules are poorly understood. Here, we report the identification of the biosynthetic gene cluster for demethoxyviridin, consisting of 19 genes, and amo ...[more]