Ontology highlight
ABSTRACT:
SUBMITTER: Yang HJ
PROVIDER: S-EPMC5943555 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Yang Hai-Jie HJ Shi Xiang X Ju Fei F Hao Bei-Ning BN Ma Shuang-Ping SP Wang Lei L Cheng Bin-Feng BF Wang Mian M
Frontiers in neuroscience 20180503
The cold shock protein RBM3 can mediate mild hypothermia-related protection in neurodegeneration such as Alzheimer's disease. However, it remains unclear whether RBM3 and mild hypothermia provide same protection in model of Parkinson's disease (PD), the second most common neurodegenerative disorder. In this study, human SH-SY5Y neuroblastoma cells subjected to insult by 1-methyl-4-phenylpyridinium (MPP<sup>+</sup>) served as an <i>in-vitro</i> model of PD. Mild hypothermia (32°C) aggravated MPP< ...[more]