Unknown

Dataset Information

0

Semisynthesis and Biological Evaluation of Oleanolic Acid 3-O-β-d-Glucuronopyranoside Derivatives for Protecting H9c2 Cardiomyoblasts against H₂O₂-Induced Injury.


ABSTRACT: A series of novel oleanolic acid 3-O-β-d-glucuronopyranoside derivatives have been designed and synthesized. Biological evaluation has indicated that some of the synthesized compounds exhibit moderate to good activity against H₂O₂-induced injury in rat myocardial cells (H9c2). Particularly, derivative 28-N-isobutyl ursolic amide 3-O-β-d-galactopyranoside (8a) exhibited a greater protective effect than the positive control oleanolic acid 3-O-β-d-glucuronopyranoside, indicating that it possesses a great potential for further development as a cardiovascular disease modulator by structural modification.

SUBMITTER: Tian Y 

PROVIDER: S-EPMC5943939 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7957939 | biostudies-literature
| S-EPMC10135342 | biostudies-literature
2014-12-30 | GSE34076 | GEO
| S-EPMC5703861 | biostudies-literature
| S-EPMC5099414 | biostudies-literature
| S-EPMC10810863 | biostudies-literature
| S-EPMC11312724 | biostudies-literature
| S-EPMC6150249 | biostudies-other
| S-EPMC10932252 | biostudies-literature
| S-EPMC10472865 | biostudies-literature