Ontology highlight
ABSTRACT:
SUBMITTER: Sun S
PROVIDER: S-EPMC5943947 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20171223 1
Both EGFR and VEGFR-2 play a critical role in tumor growth, angiogenesis and metastasis, and targeting EGFR and VEGFR-2 simultaneously represents a promising approach to cancer treatment. In this work, a series of novel quinazoline- and thiourea-containing sorafenib analogs (<b>10a</b>-<b>v</b>) were designed and synthesized as EGFR and VEGFR-2 dual TK inhibitors. Their in vitro enzymatic inhibitory activities against EGFR and VEGFR-2, and antiproliferative activities against HCT-116, MCF-7 and ...[more]