EBI2 contributes to the induction of thymic central tolerance in mice by promoting rapid motility of medullary thymocytes.

ABSTRACT: Maturing thymocytes enter the thymic medulla, where they encounter numerous self-antigens presented by antigen presenting cells (APCs). Those thymocytes that are strongly self-reactive undergo either negative selection or diversion into the regulatory T-cell lineage. Although the majority of the proteome is expressed in the medulla, many self-antigens are expressed by only a minor fraction of medullary APCs; thus, thymocytes must efficiently enter the medulla and scan APCs to ensure central tolerance. Chemokine receptors promote lymphocyte migration, organization within tissues, and interactions with APCs in lymphoid organs. The chemokine receptor EBI2 governs localization of T cells, B cells, and dendritic cells (DCs) during immune responses in secondary lymphoid organs. However, the role

SUBMITTER: Ki S 

PROVIDER: S-EPMC5944344 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature