Ontology highlight
ABSTRACT:
SUBMITTER: Sun C
PROVIDER: S-EPMC5944839 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Sun Chaoyang C Yin Jun J Fang Yong Y Chen Jian J Jeong Kang Jin KJ Chen Xiaohua X Vellano Christopher P CP Ju Zhenlin Z Zhao Wei W Zhang Dong D Lu Yiling Y Meric-Bernstam Funda F Yap Timothy A TA Hattersley Maureen M O'Connor Mark J MJ Chen Huawei H Fawell Stephen S Lin Shiaw-Yih SY Peng Guang G Mills Gordon B GB
Cancer cell 20180301 3
Poly(ADP-ribose) polymerase inhibitors (PARPi) are selectively active in cells with homologous recombination (HR) deficiency (HRD) caused by mutations in BRCA1, BRCA2, and other pathway members. We sought small molecules that induce HRD in HR-competent cells to induce synthetic lethality with PARPi and extend the utility of PARPi. We demonstrated that inhibition of bromodomain containing 4 (BRD4) induced HRD and sensitized cells across multiple tumor lineages to PARPi regardless of BRCA1/2, TP53 ...[more]