Ontology highlight
ABSTRACT:
SUBMITTER: Cho C
PROVIDER: S-EPMC5944969 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Cho Christine C Chande Aroon T AT Gakhar Lokesh L Hunt Jason J Ketterer Margaret R MR Apicella Michael A MA
PloS one 20180510 5
Nontypeable Haemophilus influenzae (NTHi) has been shown to form biofilms, comprised of extracellular DNA (eDNA), in the middle ear and bronchus during clinical infections. Studies in our laboratory have shown that NTHi possesses a homolog of Staphylococcus aureus thermonuclease (staphylococcal thermonuclease), NTHi nuclease (NTHi Nuc, HI_1296). This enzyme had similar size, heat stability, and divalent cation requirements to those of the staphylococcal homolog as determined by light scattering ...[more]