Ontology highlight
ABSTRACT:
SUBMITTER: Mavroudis PD
PROVIDER: S-EPMC5945012 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Mavroudis Panteleimon D PD DuBois Debra C DC Almon Richard R RR Jusko William J WJ
PloS one 20180510 5
Circadian information is maintained in mammalian tissues by a cell-autonomous network of transcriptional feedback loops that have evolved to optimally regulate tissue-specific functions. An analysis of daily gene expression in different tissues, as well as an evaluation of inter-tissue circadian variability, is crucial for a systems-level understanding of this transcriptional circuitry. Affymetrix gene chip measurements of liver, muscle, adipose, and lung tissues were obtained from a rich time s ...[more]