Understanding the role of the chromosome 15q25.1 in COPD through epigenetics and transcriptomics.
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ABSTRACT:
SUBMITTER: Nedeljkovic I
PROVIDER: S-EPMC5945654 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Understanding the role of the chromosome 15q25.1 in COPD through epigenetics and transcriptomics.
Nedeljkovic Ivana I Carnero-Montoro Elena E Lahousse Lies L van der Plaat Diana A DA de Jong Kim K Vonk Judith M JM van Diemen Cleo C CC Faiz Alen A van den Berge Maarten M Obeidat Ma'en M Bossé Yohan Y Nickle David C DC Consortium Bios B Uitterlinden Andre G AG van Meurs Joyce J B JJB Stricker Bruno C H BCH Brusselle Guy G GG Postma Dirkje S DS Boezen H Marike HM van Duijn Cornelia M CM Amin Najaf N
European journal of human genetics : EJHG 20180208 5
Chronic obstructive pulmonary disease (COPD) is a major health burden in adults and cigarette smoking is considered the most important environmental risk factor of COPD. Chromosome 15q25.1 locus is associated with both COPD and smoking. Our study aims at understanding the mechanism underlying the association of chromosome 15q25.1 with COPD through epigenetic and transcriptional variation in a population-based setting. To assess if COPD-associated variants in 15q25.1 are methylation quantitative ...[more]
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