Ontology highlight
ABSTRACT:
SUBMITTER: Warsow G
PROVIDER: S-EPMC5945671 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Warsow Gregor G Hübschmann Daniel D Kleinheinz Kortine K Nientiedt Cathleen C Heller Martina M Van Coile Laura L Tolstov Yanis Y Trennheuser Lukas L Wieczorek Kathrin K Pecqueux Carine C Gasch Claudia C Kuru Timur T Nyarangi-Dix Joanne J Hatiboglu Gencay G Teber Dogu D Perner Sven S Stenzinger Albrecht A Roth Wilfried W Hadaschik Boris B Pahernik Sascha S Jäger Dirk D Grüllich Carsten C Duensing Anette A Eils Roland R Schlesner Matthias M Sültmann Holger H Hohenfellner Markus M Duensing Stefan S
Scientific reports 20180510 1
A venous tumor thrombus (VTT) is a potentially lethal complication of renal cell carcinoma (RCC) but virtually nothing is known about the underlying natural history. Based on our observation that venous thrombi contain significant numbers of viable tumor cells, we applied multiregion whole exome sequencing to a total of 37 primary tumor and VTT samples including normal tissue specimens from five consecutive patients. Our findings demonstrate mutational heterogeneity between primary tumor and VTT ...[more]