Endogenous hepcidin synthesis protects the distal nephron against hemin and hemoglobin mediated necroptosis.
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ABSTRACT:
SUBMITTER: van Swelm RPL
PROVIDER: S-EPMC5945780 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Endogenous hepcidin synthesis protects the distal nephron against hemin and hemoglobin mediated necroptosis.
van Swelm Rachel P L RPL Vos Madelon M Verhoeven Frank F Thévenod Frank F Swinkels Dorine W DW
Cell death & disease 20180501 5
Hemoglobinuria is associated with kidney injury in various hemolytic pathologies. Currently, there is no treatment available and its pathophysiology is not completely understood. Here we studied the potential detrimental effects of hemoglobin (Hb) exposure to the distal nephron (DN). Involvement of the DN in Hb kidney injury was suggested by the induction of renal hepcidin synthesis (p < 0.001) in mice repeatedly injected with intravenous Hb. Moreover, the hepcidin induction was associated with ...[more]
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